Confidence Intervals for Heterogeneity Measures in Meta-analysis

Confidence intervals for heterogeneity measures in meta-analysis.

Two methods of quantifying heterogeneity between studies in meta-analysis were studied. One method quantified the proportion of the total variance of the effect estimate due to variation between studies (RI), and the other calibrated the variance between studies to the size of the effect itself through a between-study coefficient of variation (CVB). Bootstrap and asymptotic confidence intervals...

Computing Confidence Intervals for Common IR Measures

Confidence intervals quantify the uncertainty in an average and offer a robust alternative to hypothesis testing. We measure the performance of standard and bootstrapped confidence intervals on a number of common IR measures using several TREC and NTCIR collections. The performance of an interval is its empirical coverage of the estimated statistic. We find that both standard and bootstrapped i...

Generalized Confidence Intervals and Fiducial Intervals for Some Epidemiological Measures

For binary outcome data from epidemiological studies, this article investigates the interval estimation of several measures of interest in the absence or presence of categorical covariates. When covariates are present, the logistic regression model as well as the log-binomial model are investigated. The measures considered include the common odds ratio (OR) from several studies, the number need...

Evolution of Heterogeneity (I2) Estimates and Their 95% Confidence Intervals in Large Meta-Analyses

BACKGROUND Assessment of heterogeneity is essential in systematic reviews and meta-analyses of clinical trials. The most commonly used heterogeneity measure, I(2), provides an estimate of the proportion of variability in a meta-analysis that is explained by differences between the included trials rather than by sampling error. Recent studies have raised concerns about the reliability of I(2) es...

Bootstrapping Confidence Intervals For Robust Measures Of Association